Duloxetine — Drug Interactions, Alcohol & Pregnancy Guide
Last reviewed: · Source: US FDA drug label database · 247CanITakeWith Editorial Team
- Duloxetine is a SNRI (Serotonin-Noradrenaline Reuptake Inhibitor) used for Depression.
- Alcohol: Avoid alcohol with duloxetine — the combination increases liver enzyme levels and may cause liver damage, in addition to worsening depression.
- Pregnancy: Duloxetine in pregnancy should be reviewed with your GP — an individualised risk-benefit assessment is needed, and stopping suddenly must be avoided.
About Duloxetine
Duloxetine is an SNRI antidepressant also used for nerve pain and anxiety. Unlike other SSRIs, it carries a specific liver toxicity warning with alcohol use. Avoid substantial alcohol use with duloxetine.
Also sold as: Cymbalta, Yentreve
Duloxetine at a glance
Duloxetine is classed as snri (serotonin-noradrenaline reuptake inhibitor) and is used for depression, generalised anxiety disorder, neuropathic pain, fibromyalgia, stress urinary incontinence. It is a prescription medicine, so doses and combinations should always be agreed with your prescriber or pharmacist.
Typical adult dosing guidance: 60-120mg once daily. Your own label or prescription always takes priority over general figures.
Interactions most often flagged
- Alcohol
- Tramadol
- Pregnancy
Before you combine Duloxetine with anything new
- Read the patient information leaflet for both products.
- Keep one up-to-date list of every medicine and supplement you take.
- Ask a pharmacist — it is free and takes a couple of minutes.
- Seek urgent medical help if you feel seriously unwell after combining medicines.
Duloxetine and Alcohol
Avoid alcohol with duloxetine — the combination increases liver enzyme levels and may cause liver damage, in addition to worsening depression.
Full guide →Duloxetine in Pregnancy
Duloxetine in pregnancy should be reviewed with your GP — an individualised risk-benefit assessment is needed, and stopping suddenly must be avoided.
Full guide →More in this category: antidepressants
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Frequently Asked Questions
What is Duloxetine used for?
Duloxetine is a SNRI (Serotonin-Noradrenaline Reuptake Inhibitor) used for Depression, Generalised anxiety disorder, Neuropathic pain, Fibromyalgia, Stress urinary incontinence.
What is the maximum adult dose of Duloxetine?
The maximum adult dose is 60-120mg once daily. This is general guidance — always follow the dose on your prescription or product label, and check with a pharmacist if you're unsure.
Can I drink alcohol with Duloxetine?
Avoid alcohol with duloxetine — the combination increases liver enzyme levels and may cause liver damage, in addition to worsening depression.
Is Duloxetine safe to take during pregnancy?
Duloxetine in pregnancy should be reviewed with your GP — an individualised risk-benefit assessment is needed, and stopping suddenly must be avoided.
Is Duloxetine available over the counter in the UK?
Duloxetine is prescription-only in the UK.
What should I check before taking Duloxetine with other medicines?
The interactions most often flagged for Duloxetine are: alcohol, tramadol, pregnancy. Tell your pharmacist or prescriber about everything you take, including over-the-counter products, supplements and herbal remedies, before combining it with anything new.
What are the brand names for Duloxetine?
Duloxetine is sold under brand names including Cymbalta, Yentreve. The active ingredient is the same, so check labels carefully to avoid doubling up on it.
Do I need a prescription for Duloxetine?
Duloxetine is a prescription medicine, so take it exactly as your prescriber directed and ask them before changing the dose.
Not sure if Duloxetine is safe with your other medications?
HealthLabs.com lets you check liver enzyme or kidney function levels before combining medications long-term — no GP referral needed.
Check your levels at HealthLabs →Always speak to your pharmacist or GP for personalised medical advice. Affiliate link — we may earn a commission.