Pregabalin — Drug Interactions, Alcohol & Pregnancy Guide
Last reviewed: · Source: US FDA drug label database · 247CanITakeWith Editorial Team
- Pregabalin is a Gabapentinoid / Anticonvulsant used for Neuropathic pain.
- Alcohol: Avoid — pregabalin and alcohol together cause dangerous additive CNS depression, including severe sedation and respiratory risk.
- This page covers 1 specific drug combination with Pregabalin.
About Pregabalin
Pregabalin is a controlled drug (Class C, Schedule 3) in the UK. It is used for nerve pain, epilepsy, and anxiety. Like gabapentin, it carries significant misuse and overdose risk, particularly when combined with opioids or alcohol.
Also sold as: Lyrica
Pregabalin at a glance
Pregabalin is classed as gabapentinoid / anticonvulsant and is used for neuropathic pain, fibromyalgia, epilepsy, generalised anxiety disorder. It is a prescription medicine, so doses and combinations should always be agreed with your prescriber or pharmacist.
Typical adult dosing guidance: 150-600mg daily in divided doses. Your own label or prescription always takes priority over general figures.
Interactions most often flagged
- Tramadol
- Alcohol
- Opioids
- Gabapentin
Before you combine Pregabalin with anything new
- Read the patient information leaflet for both products.
- Keep one up-to-date list of every medicine and supplement you take.
- Ask a pharmacist — it is free and takes a couple of minutes.
- Seek urgent medical help if you feel seriously unwell after combining medicines.
Pregabalin and Alcohol
Avoid — pregabalin and alcohol together cause dangerous additive CNS depression, including severe sedation and respiratory risk.
Full guide →Pregabalin — Drug Combinations
More in this category: neuropathic
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Frequently Asked Questions
What is Pregabalin used for?
Pregabalin is a Gabapentinoid / Anticonvulsant used for Neuropathic pain, Fibromyalgia, Epilepsy, Generalised anxiety disorder.
What is the maximum adult dose of Pregabalin?
The maximum adult dose is 150-600mg daily in divided doses. This is general guidance — always follow the dose on your prescription or product label, and check with a pharmacist if you're unsure.
Can I drink alcohol with Pregabalin?
Avoid — pregabalin and alcohol together cause dangerous additive CNS depression, including severe sedation and respiratory risk.
Is Pregabalin available over the counter in the UK?
Pregabalin is prescription-only in the UK.
What should I check before taking Pregabalin with other medicines?
The interactions most often flagged for Pregabalin are: tramadol, alcohol, opioids, gabapentin. Tell your pharmacist or prescriber about everything you take, including over-the-counter products, supplements and herbal remedies, before combining it with anything new.
What are the brand names for Pregabalin?
Pregabalin is sold under brand names including Lyrica. The active ingredient is the same, so check labels carefully to avoid doubling up on it.
Do I need a prescription for Pregabalin?
Pregabalin is a prescription medicine, so take it exactly as your prescriber directed and ask them before changing the dose.
Not sure if Pregabalin is safe with your other medications?
HealthLabs.com lets you check liver enzyme or kidney function levels before combining medications long-term — no GP referral needed.
Check your levels at HealthLabs →Always speak to your pharmacist or GP for personalised medical advice. Affiliate link — we may earn a commission.