Can You Take Atorvastatin with Ibuprofen?
Last reviewed: · Source: US FDA drug label database
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Atorvastatin and ibuprofen can be taken together — there is no significant drug interaction between them.
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Is it safe to take Atorvastatin with Ibuprofen?
There is no significant pharmacokinetic or pharmacodynamic interaction between atorvastatin and ibuprofen. Ibuprofen does not affect how atorvastatin works or how it is cleared from the body. Both are widely used drugs often taken by the same patients (cardiovascular risk factors frequently occur with inflammatory conditions). Standard precautions for each drug apply independently: ibuprofen should be taken with food, and regular NSAID use should be reviewed in anyone with cardiovascular disease.
How do Atorvastatin and Ibuprofen interact?
Atorvastatin is metabolised primarily by CYP3A4; ibuprofen by CYP2C9. No shared metabolic pathway, no protein-binding displacement of clinical significance. No pharmacodynamic overlap.
Data sourced from the US Food and Drug Administration (FDA) drug label database: OpenFDA atorvastatin and ibuprofen labels — no interaction listed.
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Monitor your blood pressure at home — especially important when starting or adjusting medication.
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Individual drug cautions still apply: ibuprofen should be used cautiously in patients with heart disease, hypertension or kidney impairment — groups who are often already on statins. The combination itself adds no extra risk.
For weight-based or dosage calculations, our dosage calculators can help. If you're tracking what you eat alongside your medication, 247CalorieCheck's food and nutrition checker is worth a look too.
What if I've already taken Atorvastatin and Ibuprofen?
No action needed — this is a safe combination.
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Not sure if this combination is safe for your specific situation?
HealthLabs.com lets you check liver enzyme or kidney function levels before combining medications long-term — no GP referral needed.
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Frequently Asked Questions
Can I take ibuprofen with atorvastatin?
Yes — there's no significant interaction. Take ibuprofen with food as usual.
Do statins interact with NSAIDs?
Atorvastatin does not interact with NSAIDs. The statin-NSAID interaction concern relates to simvastatin and some CYP3A4 inhibitors, not NSAIDs.
Is paracetamol or ibuprofen better with atorvastatin?
Both are compatible. Paracetamol is preferred in people with cardiovascular disease or kidney problems because it lacks ibuprofen's cardiovascular and renal risks.
Can I take ibuprofen if I'm on cholesterol tablets?
If you're on atorvastatin (Lipitor), yes — no interaction. Some other cholesterol medications have different interactions; always check with your pharmacist.