Ibuprofen — Drug Interactions, Alcohol & Pregnancy Guide
Last reviewed: · Source: US FDA drug label database · 247CanITakeWith Editorial Team
- Ibuprofen is a NSAID (Non-Steroidal Anti-Inflammatory Drug) used for Pain relief.
- Alcohol: Avoid combining ibuprofen and alcohol — both irritate the stomach lining and together significantly increase the risk of stomach bleeding.
- Pregnancy: Avoid ibuprofen in pregnancy — particularly in the third trimester, where it can cause serious complications including premature closure of the fetal ductus arteriosus.
- This page covers 15 specific drug combinations with Ibuprofen.
About Ibuprofen
Ibuprofen is one of the most widely used over-the-counter painkillers in the UK. It treats pain, reduces fever, and reduces inflammation. Common forms include tablets (200mg, 400mg), gel (Ibugel), and liquid.
Also sold as: Nurofen, Advil, Motrin, Brufen, Calprofen
Ibuprofen at a glance
Ibuprofen is classed as nsaid (non-steroidal anti-inflammatory drug) and is used for pain relief, fever reduction, inflammation. It can be bought over the counter in the UK, but that does not mean it is safe with everything — check the label and ask a pharmacist if you take other medicines.
Typical adult dosing guidance: 400mg three times daily (OTC); up to 600mg three times daily (prescription). Your own label or prescription always takes priority over general figures.
Interactions most often flagged
- Aspirin
- Warfarin
- Metformin
- Paracetamol
- Alcohol
- Pregnancy
Before you combine Ibuprofen with anything new
- Read the patient information leaflet for both products.
- Keep one up-to-date list of every medicine and supplement you take.
- Ask a pharmacist — it is free and takes a couple of minutes.
- Seek urgent medical help if you feel seriously unwell after combining medicines.
Ibuprofen and Alcohol
Avoid combining ibuprofen and alcohol — both irritate the stomach lining and together significantly increase the risk of stomach bleeding.
Full guide →Ibuprofen in Pregnancy
Avoid ibuprofen in pregnancy — particularly in the third trimester, where it can cause serious complications including premature closure of the fetal ductus arteriosus.
Full guide →Ibuprofen — Drug Combinations
More in this category: painkillers
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Frequently Asked Questions
What is Ibuprofen used for?
Ibuprofen is a NSAID (Non-Steroidal Anti-Inflammatory Drug) used for Pain relief, Fever reduction, Inflammation.
What is the maximum adult dose of Ibuprofen?
The maximum adult dose is 400mg three times daily (OTC); up to 600mg three times daily (prescription). This is general guidance — always follow the dose on your prescription or product label, and check with a pharmacist if you're unsure.
Can I drink alcohol with Ibuprofen?
Avoid combining ibuprofen and alcohol — both irritate the stomach lining and together significantly increase the risk of stomach bleeding.
Is Ibuprofen safe to take during pregnancy?
Avoid ibuprofen in pregnancy — particularly in the third trimester, where it can cause serious complications including premature closure of the fetal ductus arteriosus.
Is Ibuprofen available over the counter in the UK?
Yes, Ibuprofen is available over the counter in the UK.
What should I check before taking Ibuprofen with other medicines?
The interactions most often flagged for Ibuprofen are: aspirin, warfarin, metformin, paracetamol, alcohol, pregnancy. Tell your pharmacist or prescriber about everything you take, including over-the-counter products, supplements and herbal remedies, before combining it with anything new.
What are the brand names for Ibuprofen?
Ibuprofen is sold under brand names including Nurofen, Advil, Motrin, Brufen, Calprofen. The active ingredient is the same, so check labels carefully to avoid doubling up on it.
Do I need a prescription for Ibuprofen?
Ibuprofen does not need a prescription in the UK, but a pharmacist can still advise whether it suits you alongside your other medicines.
Not sure if Ibuprofen is safe with your other medications?
HealthLabs.com lets you check liver enzyme or kidney function levels before combining medications long-term — no GP referral needed.
Check your levels at HealthLabs →Always speak to your pharmacist or GP for personalised medical advice. Affiliate link — we may earn a commission.