Codeine — Drug Interactions, Alcohol & Pregnancy Guide
Last reviewed: · Source: US FDA drug label database · 247CanITakeWith Editorial Team
- Codeine is a Opioid analgesic used for Moderate to severe pain.
- Alcohol: Avoid — codeine and alcohol together cause dangerous respiratory depression and significantly increase overdose risk.
- Pregnancy: Avoid codeine in pregnancy — it can cause neonatal opioid withdrawal syndrome and respiratory depression in the newborn if used near delivery.
- This page covers 5 specific drug combinations with Codeine.
About Codeine
Codeine is a mild opioid painkiller available over-the-counter in low-dose combination products (e.g. co-codamol 8/500) and on prescription in higher doses. It converts to morphine in the liver.
Also sold as: Codeine phosphate, Paracodol (with paracetamol), Nurofen Plus (with ibuprofen)
Codeine at a glance
Codeine is classed as opioid analgesic and is used for moderate to severe pain, cough suppression, diarrhoea. It can be bought over the counter in the UK, but that does not mean it is safe with everything — check the label and ask a pharmacist if you take other medicines.
Typical adult dosing guidance: 30-60mg every 4 hours, maximum 240mg in 24 hours. Your own label or prescription always takes priority over general figures.
Interactions most often flagged
- Paracetamol
- Ibuprofen
- Diazepam
- Alcohol
- Pregnancy
- Sertraline
Before you combine Codeine with anything new
- Read the patient information leaflet for both products.
- Keep one up-to-date list of every medicine and supplement you take.
- Ask a pharmacist — it is free and takes a couple of minutes.
- Seek urgent medical help if you feel seriously unwell after combining medicines.
Codeine and Alcohol
Avoid — codeine and alcohol together cause dangerous respiratory depression and significantly increase overdose risk.
Full guide →Codeine in Pregnancy
Avoid codeine in pregnancy — it can cause neonatal opioid withdrawal syndrome and respiratory depression in the newborn if used near delivery.
Full guide →Codeine — Drug Combinations
More in this category: painkillers
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Frequently Asked Questions
What is Codeine used for?
Codeine is a Opioid analgesic used for Moderate to severe pain, Cough suppression, Diarrhoea.
What is the maximum adult dose of Codeine?
The maximum adult dose is 30-60mg every 4 hours, maximum 240mg in 24 hours. This is general guidance — always follow the dose on your prescription or product label, and check with a pharmacist if you're unsure.
Can I drink alcohol with Codeine?
Avoid — codeine and alcohol together cause dangerous respiratory depression and significantly increase overdose risk.
Is Codeine safe to take during pregnancy?
Avoid codeine in pregnancy — it can cause neonatal opioid withdrawal syndrome and respiratory depression in the newborn if used near delivery.
Is Codeine available over the counter in the UK?
Yes, Codeine is available over the counter in the UK.
What should I check before taking Codeine with other medicines?
The interactions most often flagged for Codeine are: paracetamol, ibuprofen, diazepam, alcohol, pregnancy, sertraline. Tell your pharmacist or prescriber about everything you take, including over-the-counter products, supplements and herbal remedies, before combining it with anything new.
What are the brand names for Codeine?
Codeine is sold under brand names including Codeine phosphate, Paracodol (with paracetamol), Nurofen Plus (with ibuprofen). The active ingredient is the same, so check labels carefully to avoid doubling up on it.
Do I need a prescription for Codeine?
Codeine does not need a prescription in the UK, but a pharmacist can still advise whether it suits you alongside your other medicines.
Not sure if Codeine is safe with your other medications?
HealthLabs.com lets you check liver enzyme or kidney function levels before combining medications long-term — no GP referral needed.
Check your levels at HealthLabs →Always speak to your pharmacist or GP for personalised medical advice. Affiliate link — we may earn a commission.