Paracetamol — Drug Interactions, Alcohol & Pregnancy Guide
Last reviewed: · Source: US FDA drug label database · 247CanITakeWith Editorial Team
- Paracetamol is a Analgesic / Antipyretic used for Pain relief.
- Alcohol: Use caution — regular heavy drinking with paracetamol can cause liver damage, though occasional moderate use is generally safe.
- Pregnancy: Paracetamol is the recommended painkiller throughout pregnancy — use the lowest effective dose for the shortest time.
- This page covers 6 specific drug combinations with Paracetamol.
About Paracetamol
Paracetamol (known as acetaminophen in the US) is the most widely used painkiller in the UK. It is safe for most people including pregnant women and children. It does not cause stomach irritation like NSAIDs.
Also sold as: Calpol, Panadol, Tylenol, Disprol
US name: Acetaminophen
Paracetamol at a glance
Paracetamol is classed as analgesic / antipyretic and is used for pain relief, fever reduction. It can be bought over the counter in the UK, but that does not mean it is safe with everything — check the label and ask a pharmacist if you take other medicines.
Typical adult dosing guidance: 1g (1000mg) up to four times daily, maximum 4g in 24 hours. Your own label or prescription always takes priority over general figures.
Interactions most often flagged
- Codeine
- Alcohol
- Warfarin
- Pregnancy
- Breastfeeding
Before you combine Paracetamol with anything new
- Read the patient information leaflet for both products.
- Keep one up-to-date list of every medicine and supplement you take.
- Ask a pharmacist — it is free and takes a couple of minutes.
- Seek urgent medical help if you feel seriously unwell after combining medicines.
Paracetamol and Alcohol
Use caution — regular heavy drinking with paracetamol can cause liver damage, though occasional moderate use is generally safe.
Full guide →Paracetamol in Pregnancy
Paracetamol is the recommended painkiller throughout pregnancy — use the lowest effective dose for the shortest time.
Full guide →Paracetamol — Drug Combinations
More in this category: painkillers
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Frequently Asked Questions
What is Paracetamol used for?
Paracetamol is a Analgesic / Antipyretic used for Pain relief, Fever reduction.
What is the maximum adult dose of Paracetamol?
The maximum adult dose is 1g (1000mg) up to four times daily, maximum 4g in 24 hours. This is general guidance — always follow the dose on your prescription or product label, and check with a pharmacist if you're unsure.
Can I drink alcohol with Paracetamol?
Use caution — regular heavy drinking with paracetamol can cause liver damage, though occasional moderate use is generally safe.
Is Paracetamol safe to take during pregnancy?
Paracetamol is the recommended painkiller throughout pregnancy — use the lowest effective dose for the shortest time.
Is Paracetamol available over the counter in the UK?
Yes, Paracetamol is available over the counter in the UK.
What should I check before taking Paracetamol with other medicines?
The interactions most often flagged for Paracetamol are: codeine, alcohol, warfarin, pregnancy, breastfeeding. Tell your pharmacist or prescriber about everything you take, including over-the-counter products, supplements and herbal remedies, before combining it with anything new.
What are the brand names for Paracetamol?
Paracetamol is sold under brand names including Calpol, Panadol, Tylenol, Disprol. The active ingredient is the same, so check labels carefully to avoid doubling up on it.
Do I need a prescription for Paracetamol?
Paracetamol does not need a prescription in the UK, but a pharmacist can still advise whether it suits you alongside your other medicines.
Not sure if Paracetamol is safe with your other medications?
HealthLabs.com lets you check liver enzyme or kidney function levels before combining medications long-term — no GP referral needed.
Check your levels at HealthLabs →Always speak to your pharmacist or GP for personalised medical advice. Affiliate link — we may earn a commission.