Naproxen — Drug Interactions, Alcohol & Pregnancy Guide
Last reviewed: · Source: US FDA drug label database · 247CanITakeWith Editorial Team
- Naproxen is a NSAID used for Pain relief.
- Alcohol: Avoid alcohol with naproxen — like ibuprofen, both irritate the stomach lining and together increase the risk of bleeding ulcers.
- Pregnancy: Avoid naproxen in pregnancy — like all NSAIDs it risks fetal kidney and heart complications, especially from 20 weeks onwards.
- This page covers 3 specific drug combinations with Naproxen.
About Naproxen
Naproxen is an NSAID available over-the-counter (Aleve, 220mg) and on prescription (up to 1000mg/day). Its longer half-life (12-17 hours) means twice-daily dosing. Like ibuprofen, it carries GI and cardiovascular risks.
Also sold as: Naprosyn, Aleve, Feminax Ultra
Naproxen at a glance
Naproxen is classed as nsaid and is used for pain relief, inflammation, period pain, arthritis, gout. It can be bought over the counter in the UK, but that does not mean it is safe with everything — check the label and ask a pharmacist if you take other medicines.
Typical adult dosing guidance: 500mg twice daily (prescription); 220-440mg OTC. Your own label or prescription always takes priority over general figures.
Interactions most often flagged
- Alcohol
- Warfarin
- Aspirin
- Pregnancy
Before you combine Naproxen with anything new
- Read the patient information leaflet for both products.
- Keep one up-to-date list of every medicine and supplement you take.
- Ask a pharmacist — it is free and takes a couple of minutes.
- Seek urgent medical help if you feel seriously unwell after combining medicines.
Naproxen and Alcohol
Avoid alcohol with naproxen — like ibuprofen, both irritate the stomach lining and together increase the risk of bleeding ulcers.
Full guide →Naproxen in Pregnancy
Avoid naproxen in pregnancy — like all NSAIDs it risks fetal kidney and heart complications, especially from 20 weeks onwards.
Full guide →Naproxen — Drug Combinations
More in this category: painkillers
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Frequently Asked Questions
What is Naproxen used for?
Naproxen is a NSAID used for Pain relief, Inflammation, Period pain, Arthritis, Gout.
What is the maximum adult dose of Naproxen?
The maximum adult dose is 500mg twice daily (prescription); 220-440mg OTC. This is general guidance — always follow the dose on your prescription or product label, and check with a pharmacist if you're unsure.
Can I drink alcohol with Naproxen?
Avoid alcohol with naproxen — like ibuprofen, both irritate the stomach lining and together increase the risk of bleeding ulcers.
Is Naproxen safe to take during pregnancy?
Avoid naproxen in pregnancy — like all NSAIDs it risks fetal kidney and heart complications, especially from 20 weeks onwards.
Is Naproxen available over the counter in the UK?
Yes, Naproxen is available over the counter in the UK.
What should I check before taking Naproxen with other medicines?
The interactions most often flagged for Naproxen are: alcohol, warfarin, aspirin, pregnancy. Tell your pharmacist or prescriber about everything you take, including over-the-counter products, supplements and herbal remedies, before combining it with anything new.
What are the brand names for Naproxen?
Naproxen is sold under brand names including Naprosyn, Aleve, Feminax Ultra. The active ingredient is the same, so check labels carefully to avoid doubling up on it.
Do I need a prescription for Naproxen?
Naproxen does not need a prescription in the UK, but a pharmacist can still advise whether it suits you alongside your other medicines.
Not sure if Naproxen is safe with your other medications?
HealthLabs.com lets you check liver enzyme or kidney function levels before combining medications long-term — no GP referral needed.
Check your levels at HealthLabs →Always speak to your pharmacist or GP for personalised medical advice. Affiliate link — we may earn a commission.