Can You Take Co-Amoxiclav with Ibuprofen?
Last reviewed: · Source: US FDA drug label database
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Co-amoxiclav and ibuprofen can be taken together — there's no significant drug interaction between them.
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Is it safe to take Co-Amoxiclav with Ibuprofen?
There is no pharmacokinetic or pharmacodynamic interaction between co-amoxiclav (Augmentin) and ibuprofen. Both are commonly used together during infections with fever or pain. Take ibuprofen with food to reduce its stomach-irritating effect, and note that co-amoxiclav already has a higher rate of GI side effects than plain amoxicillin — so taking ibuprofen without food may worsen stomach upset. Complete the full antibiotic course.
How do Co-Amoxiclav and Ibuprofen interact?
Co-amoxiclav is renally excreted with no CYP involvement; ibuprofen is CYP2C9 metabolised. No shared pathways, no pharmacodynamic overlap. Standard individual drug cautions (ibuprofen: NSAID GI/renal risks; co-amoxiclav: GI side effects from clavulanic acid) apply independently.
Data sourced from the US Food and Drug Administration (FDA) drug label database: OpenFDA co-amoxiclav and ibuprofen labels — no interaction listed.
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Check Price →Keep track of your antibiotic course to make sure you complete the full course.
Check Price →Stay well hydrated during antibiotic treatment — most antibiotics require plenty of water.
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Shop Herbspro →Who should be careful?
People with stomach problems (the combination of co-amoxiclav's GI side effects plus ibuprofen can be uncomfortable). Take both with food if possible.
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What if I've already taken Co-Amoxiclav and Ibuprofen?
No action needed. Take both with food and complete the antibiotic course.
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Not sure if this combination is safe for your specific situation?
HealthLabs.com lets you check liver enzyme or kidney function levels before combining medications long-term — no GP referral needed.
Check your levels at HealthLabs →Always speak to your pharmacist or GP for personalised medical advice. Affiliate link — we may earn a commission.
Frequently Asked Questions
Can I take ibuprofen with co-amoxiclav (Augmentin)?
Yes — no significant interaction. Take both with food to reduce stomach upset, as co-amoxiclav already commonly causes GI side effects.
Can I take paracetamol instead of ibuprofen with co-amoxiclav?
Yes — paracetamol is equally safe with co-amoxiclav and is gentler on the stomach.
Why does co-amoxiclav upset my stomach even without ibuprofen?
The clavulanic acid component directly irritates the gut. Taking it with food, avoiding alcohol, and completing the course (rather than stopping early) all help.
Can I take co-codamol with co-amoxiclav?
Yes — co-codamol (paracetamol + codeine) is compatible with co-amoxiclav for short-term use.