Co-Amoxiclav — Drug Interactions, Alcohol & Pregnancy Guide
Last reviewed: · Source: US FDA drug label database · 247CanITakeWith Editorial Team
- Co-Amoxiclav is a Penicillin + beta-lactamase inhibitor antibiotic used for Skin and soft tissue infections.
- Alcohol: You can drink alcohol with co-amoxiclav (Augmentin) in small amounts — unlike metronidazole there is no dangerous reaction — but alcohol can worsen the nausea and diarrhoea this antibiotic commonly causes.
- Pregnancy: Co-amoxiclav can be used in pregnancy when necessary, but it's not the first choice — plain amoxicillin or other pregnancy-safe antibiotics are preferred where possible.
- This page covers 1 specific drug combination with Co-Amoxiclav.
About Co-Amoxiclav
Co-amoxiclav (Augmentin) is amoxicillin combined with clavulanic acid, which protects the antibiotic from resistance. It has a higher rate of GI side effects (diarrhoea, nausea) than plain amoxicillin. Take with food to reduce GI effects.
Also sold as: Augmentin
Co-Amoxiclav at a glance
Co-Amoxiclav is classed as penicillin + beta-lactamase inhibitor antibiotic and is used for skin and soft tissue infections, dental infections, respiratory infections, utis (when other antibiotics unsuitable). It is a prescription medicine, so doses and combinations should always be agreed with your prescriber or pharmacist.
Typical adult dosing guidance: 375mg or 625mg three times daily depending on indication. Your own label or prescription always takes priority over general figures.
Interactions most often flagged
- Alcohol
- Warfarin
Before you combine Co-Amoxiclav with anything new
- Read the patient information leaflet for both products.
- Keep one up-to-date list of every medicine and supplement you take.
- Ask a pharmacist — it is free and takes a couple of minutes.
- Seek urgent medical help if you feel seriously unwell after combining medicines.
Co-Amoxiclav and Alcohol
You can drink alcohol with co-amoxiclav (Augmentin) in small amounts — unlike metronidazole there is no dangerous reaction — but alcohol can worsen the nausea and diarrhoea this antibiotic commonly causes.
Full guide →Co-Amoxiclav in Pregnancy
Co-amoxiclav can be used in pregnancy when necessary, but it's not the first choice — plain amoxicillin or other pregnancy-safe antibiotics are preferred where possible.
Full guide →Co-Amoxiclav — Drug Combinations
More in this category: antibiotics
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Frequently Asked Questions
What is Co-Amoxiclav used for?
Co-Amoxiclav is a Penicillin + beta-lactamase inhibitor antibiotic used for Skin and soft tissue infections, Dental infections, Respiratory infections, UTIs (when other antibiotics unsuitable).
What is the maximum adult dose of Co-Amoxiclav?
The maximum adult dose is 375mg or 625mg three times daily depending on indication. This is general guidance — always follow the dose on your prescription or product label, and check with a pharmacist if you're unsure.
Can I drink alcohol with Co-Amoxiclav?
You can drink alcohol with co-amoxiclav (Augmentin) in small amounts — unlike metronidazole there is no dangerous reaction — but alcohol can worsen the nausea and diarrhoea this antibiotic commonly causes.
Is Co-Amoxiclav safe to take during pregnancy?
Co-amoxiclav can be used in pregnancy when necessary, but it's not the first choice — plain amoxicillin or other pregnancy-safe antibiotics are preferred where possible.
Is Co-Amoxiclav available over the counter in the UK?
Co-Amoxiclav is prescription-only in the UK.
What should I check before taking Co-Amoxiclav with other medicines?
The interactions most often flagged for Co-Amoxiclav are: alcohol, warfarin. Tell your pharmacist or prescriber about everything you take, including over-the-counter products, supplements and herbal remedies, before combining it with anything new.
What are the brand names for Co-Amoxiclav?
Co-Amoxiclav is sold under brand names including Augmentin. The active ingredient is the same, so check labels carefully to avoid doubling up on it.
Do I need a prescription for Co-Amoxiclav?
Co-Amoxiclav is a prescription medicine, so take it exactly as your prescriber directed and ask them before changing the dose.
Not sure if Co-Amoxiclav is safe with your other medications?
HealthLabs.com lets you check liver enzyme or kidney function levels before combining medications long-term — no GP referral needed.
Check your levels at HealthLabs →Always speak to your pharmacist or GP for personalised medical advice. Affiliate link — we may earn a commission.