Loperamide — Drug Interactions, Alcohol & Pregnancy Guide
Last reviewed: · Source: US FDA drug label database · 247CanITakeWith Editorial Team
- Loperamide is a Opioid receptor agonist (gut-selective) used for Acute diarrhoea.
About Loperamide
Loperamide (Imodium) reduces gut motility to treat diarrhoea. It does not cross the blood-brain barrier at normal doses and is not a controlled drug. Do not use for more than 48 hours without medical advice in acute diarrhoea.
Also sold as: Imodium, Dicalm
Loperamide at a glance
Loperamide is classed as opioid receptor agonist (gut-selective) and is used for acute diarrhoea, chronic diarrhoea (ibs), ileostomy output control. It can be bought over the counter in the UK, but that does not mean it is safe with everything — check the label and ask a pharmacist if you take other medicines.
Typical adult dosing guidance: 4mg initially then 2mg after each loose stool, maximum 16mg in 24 hours. Your own label or prescription always takes priority over general figures.
Our records list no major drug interactions for Loperamide at standard doses. Still tell your pharmacist about everything else you take, including supplements.
Before you combine Loperamide with anything new
- Read the patient information leaflet for both products.
- Keep one up-to-date list of every medicine and supplement you take.
- Ask a pharmacist — it is free and takes a couple of minutes.
- Seek urgent medical help if you feel seriously unwell after combining medicines.
More in this category: gastrointestinal
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Frequently Asked Questions
What is Loperamide used for?
Loperamide is a Opioid receptor agonist (gut-selective) used for Acute diarrhoea, Chronic diarrhoea (IBS), Ileostomy output control.
What is the maximum adult dose of Loperamide?
The maximum adult dose is 4mg initially then 2mg after each loose stool, maximum 16mg in 24 hours. This is general guidance — always follow the dose on your prescription or product label, and check with a pharmacist if you're unsure.
Is Loperamide available over the counter in the UK?
Yes, Loperamide is available over the counter in the UK.
Does Loperamide have major drug interactions?
Our records list no major drug interactions for Loperamide at standard doses. That does not rule out an individual risk, so still mention it to your pharmacist when you start any new medicine.
What are the brand names for Loperamide?
Loperamide is sold under brand names including Imodium, Dicalm. The active ingredient is the same, so check labels carefully to avoid doubling up on it.
Do I need a prescription for Loperamide?
Loperamide does not need a prescription in the UK, but a pharmacist can still advise whether it suits you alongside your other medicines.
Not sure if Loperamide is safe with your other medications?
HealthLabs.com lets you check liver enzyme or kidney function levels before combining medications long-term — no GP referral needed.
Check your levels at HealthLabs →Always speak to your pharmacist or GP for personalised medical advice. Affiliate link — we may earn a commission.