Omeprazole — Drug Interactions, Alcohol & Pregnancy Guide
Last reviewed: · Source: US FDA drug label database · 247CanITakeWith Editorial Team
- Omeprazole is a Proton Pump Inhibitor (PPI) used for GORD / acid reflux.
- Alcohol: Use with caution — alcohol irritates the stomach omeprazole is treating, and may slightly increase omeprazole levels in the body.
- Pregnancy: Omeprazole is sometimes used in pregnancy for severe heartburn but requires medical advice — particularly in the first trimester.
- This page covers 4 specific drug combinations with Omeprazole.
About Omeprazole
Omeprazole is a proton pump inhibitor (PPI) used to reduce stomach acid. It is available over-the-counter (10mg, 20mg) and on prescription (40mg). It is one of the most commonly prescribed drugs in the UK.
Also sold as: Losec, Prilosec
Omeprazole at a glance
Omeprazole is classed as proton pump inhibitor (ppi) and is used for gord / acid reflux, stomach ulcers, h. pylori eradication (part of triple therapy), nsaid-induced gastric protection. It can be bought over the counter in the UK, but that does not mean it is safe with everything — check the label and ask a pharmacist if you take other medicines.
Typical adult dosing guidance: 20-40mg once daily. Your own label or prescription always takes priority over general figures.
Interactions most often flagged
- Alcohol
- Metformin
- Pregnancy
- Clopidogrel
Before you combine Omeprazole with anything new
- Read the patient information leaflet for both products.
- Keep one up-to-date list of every medicine and supplement you take.
- Ask a pharmacist — it is free and takes a couple of minutes.
- Seek urgent medical help if you feel seriously unwell after combining medicines.
Omeprazole and Alcohol
Use with caution — alcohol irritates the stomach omeprazole is treating, and may slightly increase omeprazole levels in the body.
Full guide →Omeprazole in Pregnancy
Omeprazole is sometimes used in pregnancy for severe heartburn but requires medical advice — particularly in the first trimester.
Full guide →Omeprazole — Drug Combinations
More in this category: gastrointestinal
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Frequently Asked Questions
What is Omeprazole used for?
Omeprazole is a Proton Pump Inhibitor (PPI) used for GORD / acid reflux, Stomach ulcers, H. pylori eradication (part of triple therapy), NSAID-induced gastric protection.
What is the maximum adult dose of Omeprazole?
The maximum adult dose is 20-40mg once daily. This is general guidance — always follow the dose on your prescription or product label, and check with a pharmacist if you're unsure.
Can I drink alcohol with Omeprazole?
Use with caution — alcohol irritates the stomach omeprazole is treating, and may slightly increase omeprazole levels in the body.
Is Omeprazole safe to take during pregnancy?
Omeprazole is sometimes used in pregnancy for severe heartburn but requires medical advice — particularly in the first trimester.
Is Omeprazole available over the counter in the UK?
Yes, Omeprazole is available over the counter in the UK.
What should I check before taking Omeprazole with other medicines?
The interactions most often flagged for Omeprazole are: alcohol, metformin, pregnancy, clopidogrel. Tell your pharmacist or prescriber about everything you take, including over-the-counter products, supplements and herbal remedies, before combining it with anything new.
What are the brand names for Omeprazole?
Omeprazole is sold under brand names including Losec, Prilosec. The active ingredient is the same, so check labels carefully to avoid doubling up on it.
Do I need a prescription for Omeprazole?
Omeprazole does not need a prescription in the UK, but a pharmacist can still advise whether it suits you alongside your other medicines.
Not sure if Omeprazole is safe with your other medications?
HealthLabs.com lets you check liver enzyme or kidney function levels before combining medications long-term — no GP referral needed.
Check your levels at HealthLabs →Always speak to your pharmacist or GP for personalised medical advice. Affiliate link — we may earn a commission.