Can You Take Montelukast with Alcohol?
Last reviewed: · Source: US FDA drug label database
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No significant interaction between montelukast and alcohol — moderate drinking is generally fine, though alcohol is itself a trigger for asthma in many people.
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- There's no direct chemical interaction between montelukast and alcohol.
- Alcohol is itself a known asthma trigger for some people, which matters more for asthma control than any drug interaction.
- If you notice alcohol worsens your breathing symptoms, that's about your asthma, not about montelukast.
- Montelukast carries an unrelated FDA boxed warning for neuropsychiatric effects — mood or behaviour changes should always be reported to a doctor.
Is it safe to take Montelukast with Alcohol?
Montelukast (Singulair) has no pharmacokinetic or pharmacodynamic interaction with alcohol. It does not cause sedation and alcohol does not affect how it works. However, alcohol is a known asthma and allergic rhinitis trigger in many people — histamine and sulphites in wine and beer can worsen breathing. If you notice your asthma worsens after drinking, that is an asthma-alcohol interaction, not a montelukast-alcohol interaction.
How do Montelukast and Alcohol interact?
Montelukast blocks CysLT1 leukotriene receptors — no overlap with alcohol's GABA/NMDA effects. No shared CYP metabolism of clinical significance. Alcohol's effect on airways is direct: sulphites and histamine in drinks trigger bronchoconstriction in susceptible people.
Data sourced from the US Food and Drug Administration (FDA) drug label database: OpenFDA montelukast label; FDA neuropsychiatric boxed warning.
Interaction severity
Rated minor: there's no direct pharmacological interaction between montelukast and alcohol — the only relevant point is that alcohol itself can be an asthma trigger for some people, independent of the medication.
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Asthma patients who notice breathing worsens with alcohol should reduce or avoid it regardless of montelukast. Anyone with the FDA-warned neuropsychiatric effects of montelukast should minimise alcohol as it further affects mood.
What if I've already taken Montelukast and Alcohol?
No action needed unless breathing worsens after drinking, in which case use your reliever inhaler as usual.
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Not sure if this combination is safe for your specific situation?
HealthLabs.com lets you check liver enzyme or kidney function levels before combining medications long-term — no GP referral needed.
Check your levels at HealthLabs →Always speak to your pharmacist or GP for personalised medical advice. Affiliate link — we may earn a commission.
Frequently Asked Questions
Can I drink alcohol with montelukast (Singulair)?
Yes — there's no significant interaction. But alcohol can trigger asthma symptoms directly in some people, especially wine with sulphites.
Does alcohol affect montelukast?
No — alcohol doesn't change how montelukast works or how it's processed.
Why does wine worsen my asthma?
Wine contains sulphites and histamine, which are direct airway irritants in susceptible people. This is separate from any medication interaction.
Does alcohol worsen montelukast's mood side effects?
Montelukast carries an FDA boxed warning for mood and behaviour changes. Alcohol can worsen mood and anxiety independently — minimise it if you are affected.