Can You Take Montelukast with Cetirizine?
Last reviewed: · Source: US FDA drug label database
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Montelukast and cetirizine are safe and often deliberately combined for allergies and allergic asthma — they block different parts of the allergic response.
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Is it safe to take Montelukast with Cetirizine?
This is a genuinely complementary pairing: cetirizine blocks histamine while montelukast blocks leukotrienes — two separate chemical messengers in allergic reactions. Doctors frequently combine them for allergic rhinitis with asthma, or hives that don't fully respond to antihistamines alone. There is no pharmacokinetic interaction. Be aware of montelukast's own FDA boxed warning about mood and behaviour changes, which applies with or without cetirizine.
How do Montelukast and Cetirizine interact?
Cetirizine antagonises H1 receptors; montelukast antagonises cysteinyl-leukotriene CysLT1 receptors. The pathways are parallel, so blockade is complementary. Neither drug affects the other's metabolism (cetirizine is renally cleared largely unchanged; montelukast via CYP2C8/3A4).
Data sourced from the US Food and Drug Administration (FDA) drug label database: OpenFDA montelukast (boxed warning) and cetirizine labels — no interaction listed.
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Standard individual cautions: montelukast's neuropsychiatric warning (report mood changes, vivid dreams, depression, agitation — especially in children); mild drowsiness possible from cetirizine.
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What if I've already taken Montelukast and Cetirizine?
No action needed — commonly co-prescribed. Montelukast works best taken in the evening; cetirizine timing is flexible.
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Not sure if this combination is safe for your specific situation?
HealthLabs.com lets you check liver enzyme or kidney function levels before combining medications long-term — no GP referral needed.
Check your levels at HealthLabs →Always speak to your pharmacist or GP for personalised medical advice. Affiliate link — we may earn a commission.
Frequently Asked Questions
Can I take montelukast and cetirizine together?
Yes — they're often prescribed together for allergies and allergic asthma because they block different allergy pathways.
When should each be taken?
Montelukast in the evening (its licensed timing for asthma); cetirizine any consistent time — at night if it makes you drowsy.
What is the montelukast mood warning?
The FDA boxed warning covers agitation, sleep disturbance, depression and rarely suicidal thoughts. Report any mood or behaviour change promptly, especially in children.
Will the combination make me drowsy?
Montelukast is non-sedating; cetirizine causes mild drowsiness in about 1 in 10 people. Any drowsiness is from the cetirizine component.