Cetirizine — Drug Interactions, Alcohol & Pregnancy Guide
Last reviewed: · Source: US FDA drug label database · 247CanITakeWith Editorial Team
- Cetirizine is a Second-generation antihistamine used for Hay fever.
- Alcohol: Use caution — cetirizine and alcohol both cause drowsiness and together the sedative effect can be significantly enhanced.
- Pregnancy: Cetirizine is one of the preferred antihistamines in pregnancy — evidence is reassuring, though loratadine is often listed first choice.
- This page covers 2 specific drug combinations with Cetirizine.
About Cetirizine
Cetirizine is a second-generation antihistamine for allergies and hay fever. Less sedating than older antihistamines but can still cause drowsiness in some people. Take at night if drowsiness is an issue.
Also sold as: Zyrtec, Piriteze, Benadryl One A Night
Cetirizine at a glance
Cetirizine is classed as second-generation antihistamine and is used for hay fever, allergic rhinitis, urticaria (hives), allergic skin conditions. It can be bought over the counter in the UK, but that does not mean it is safe with everything — check the label and ask a pharmacist if you take other medicines.
Typical adult dosing guidance: 10mg once daily. Your own label or prescription always takes priority over general figures.
Interactions most often flagged
- Alcohol
Before you combine Cetirizine with anything new
- Read the patient information leaflet for both products.
- Keep one up-to-date list of every medicine and supplement you take.
- Ask a pharmacist — it is free and takes a couple of minutes.
- Seek urgent medical help if you feel seriously unwell after combining medicines.
Cetirizine and Alcohol
Use caution — cetirizine and alcohol both cause drowsiness and together the sedative effect can be significantly enhanced.
Full guide →Cetirizine in Pregnancy
Cetirizine is one of the preferred antihistamines in pregnancy — evidence is reassuring, though loratadine is often listed first choice.
Full guide →Cetirizine — Drug Combinations
More in this category: allergy
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Frequently Asked Questions
What is Cetirizine used for?
Cetirizine is a Second-generation antihistamine used for Hay fever, Allergic rhinitis, Urticaria (hives), Allergic skin conditions.
What is the maximum adult dose of Cetirizine?
The maximum adult dose is 10mg once daily. This is general guidance — always follow the dose on your prescription or product label, and check with a pharmacist if you're unsure.
Can I drink alcohol with Cetirizine?
Use caution — cetirizine and alcohol both cause drowsiness and together the sedative effect can be significantly enhanced.
Is Cetirizine safe to take during pregnancy?
Cetirizine is one of the preferred antihistamines in pregnancy — evidence is reassuring, though loratadine is often listed first choice.
Is Cetirizine available over the counter in the UK?
Yes, Cetirizine is available over the counter in the UK.
What should I check before taking Cetirizine with other medicines?
The interactions most often flagged for Cetirizine are: alcohol. Tell your pharmacist or prescriber about everything you take, including over-the-counter products, supplements and herbal remedies, before combining it with anything new.
What are the brand names for Cetirizine?
Cetirizine is sold under brand names including Zyrtec, Piriteze, Benadryl One A Night. The active ingredient is the same, so check labels carefully to avoid doubling up on it.
Do I need a prescription for Cetirizine?
Cetirizine does not need a prescription in the UK, but a pharmacist can still advise whether it suits you alongside your other medicines.
Not sure if Cetirizine is safe with your other medications?
HealthLabs.com lets you check liver enzyme or kidney function levels before combining medications long-term — no GP referral needed.
Check your levels at HealthLabs →Always speak to your pharmacist or GP for personalised medical advice. Affiliate link — we may earn a commission.