Chlorphenamine — Drug Interactions, Alcohol & Pregnancy Guide

Last reviewed: · Source: US FDA drug label database

About Chlorphenamine

Chlorphenamine (Piriton) is a sedating antihistamine for allergies and itching. Unlike modern antihistamines (cetirizine, loratadine), it causes significant drowsiness. Do not drive after taking it.

Also sold as: Piriton, chlorpheniramine

Drug class First-generation antihistamine
Used for Hay fever, Urticaria (hives), Allergic reactions, Itching, Hyperemesis gravidarum (part of protocols)
Max adult dose 4mg every 4-6 hours, maximum 24mg in 24 hours
OTC in UK Yes

Chlorphenamine and Alcohol

🔴 AVOID

Avoid alcohol with chlorphenamine (Piriton) — this older antihistamine is sedating on its own, and alcohol dramatically increases drowsiness, impairing driving and coordination.

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Chlorphenamine in Pregnancy

🟡 USE WITH CAUTION

Chlorphenamine (Piriton) is the most-studied antihistamine in pregnancy and is sometimes recommended when modern antihistamines are insufficient — but it causes significant sedation.

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